EPC Capturing Technology
Endothelial Progenitor Cells (EPCs) play a crucial role in vascular repair and endothelialization.
- EPCs were first described by Asahara in 1996 as circulating CD34+ cells with the potential to differentiate into endothelial cells
- EPCs are bone marrow-derived cells that are mobilized in response to tissue or vessel injury and incorporate into the sites of injury
- EPC capture is central to our healing technology
- Endothelial coverage is a histological predictor of stent thrombosis after stent placement
How does Genous facilitate EPC capture and endothelialization?
Design and Materials
The Genous CoCr stent has a unique dual helix design that provides natural conformability and tremendous radial strength without compromising its extreme flexibility.
– for lesion coverage and minimal foreshortening
Dual Helix Backbone
– for flexibility, radial strength and natural conformability
Helically Linked Sinusoidal Rings
– for scaffolding, coverage, and support
The Genous CoCr stent cells can be expanded up to 4.5 mm in diameter, enabling excellent side branch access for effective bifurcation stenting and for maintaining patency of side branches.
When Material Matters
The Genous CoCr stent is made from L605 cobalt chromium alloy, which has no molybdenum and less nickel than 316L stainless steel and MP35N cobalt chromium alloy. This caters to patients who are allergic to nickel or molybdenum and are at risk of developing restenosis.1
1. Koster, R, et al., The Lancet, 2000, 356:1895-7. Nickel and Molybdenum Contact Allergies in Patients With Coronary In-stent Restenosis.
At OrbusNeich, we remain relentless in our commitment to improving the long-term quality of life for patients.
Driven by our mission to be global leaders in life-changing vascular technologies, we work together with our physician partners to understand and meet clinical needs.
Key Clinical Findings
Note: BMS and EPC capture stents were implanted in an AV shunt in 15 patients undergoing elective PCI for up to 2 hours
Note: EPC capture stents were implanted in 384 patients.